What Are The Causes Of Zollinger Ellison Syndrome? What is Zollinger Ellison?, Some information you need to know about the symptoms of Zollinger Ellison syndrome.
What Are The Causes Of Zollinger Ellison Syndrome? What is Zollinger Ellison?
The condition in which one or more tumors called gastrinoma located in the pancreas or duodenum cause the stomach to produce too much acid is called Zollinger Ellison syndrome. Excess acid production in the stomach can lead to complications such as peptic ulcer disease, diarrhea and gastroesophageal reflux disease. In the content of our article, you, our dear friends, can find detailed answers to the questions What are the symptoms of Zollinger Ellison syndrome? and How is Zollinger Ellison syndrome treated?. So What are the causes of Zollinger Ellison syndrome?
The cause of most cases of Zollinger Ellison syndrome is unknown. A rare genetic disorder called MEN1 causes gastrinomas in about 20% to 25% of cases. Tumors called gastrinoma occurring in the pancreas and duodenum cause Zollinger Ellison syndrome. Gastrinomas secrete large amounts of a hormone called gastrin. Normally, after eating, the body secretes a small amount of gatrin and the stomach is triggered to produce acid. When gastrinomas secrete large amounts of gastrin, the stomach produces too much acid, leading to Zollinger Ellison syndrome.
Some tests are performed to confirm the clinical diagnosis of Zollinger Ellison syndrome. These; Stomach acid test, blood tests, upper gastrointestinal endoscopy and endoscopic retrograde cholangiopancreatography. ERCP is a procedure that combines upper GI endoscopy and x-rays to examine the bile ducts and pancreatic ducts. Upper gastrointestinal endoscopy is a procedure that uses an endoscope to view the mucosa of the upper digestive tract, including the esophagus, stomach and doudenum. Upper GI endoscopy may show signs of zollinger-ellison syndrome or its complications.
In addition, this test is applied to search for the causative tumors. Stomach acid test may be requested to check the pH or acidity of stomach fluids. A tube is placed through the nose into the stomach to collect a fluid sample. Stomach acid pH can be measured during upper gastrointestinal endoscopy. A blood test may also be ordered to check blood gastrin levels after eating or drinking nothing but water for a few hours. High gastrin levels may be a sign of Zollinger Ellison syndrome. You can find detailed information about the symptoms of Zollinger Ellison syndrome by continuing our article.
How Is Zollinger Ellison Syndrome Treated?
Zollinger Ellison Syndrome Symptoms
– Feeling of weakness or faintness,
– Sudden, persistent stomach pain that does not go away,
– Symptoms of bleeding in the digestive system,
– Pain during swallowing,
– Breathing problems,
– Resistant vomiting,
– Chest pain,
– Weight loss,
– Nausea or vomiting,
– Painful burning sensation in the chest,
– Burning pain in the abdomen or abdomen between the navel and the middle of the chest,
– Diarrhea which may be the only symptom.
The aim of treatment in Zollinger-Ellison syndrome patients is planned to control the increase in stomach acid and surgical removal of the tumor. Inpatient care primarily aims to control the level of stomach acid. After this situation is taken under control, imaging studies are performed to determine the location and size of the tumor. Patients who are candidates for surgical resection should be evaluated for tumor removal. For patients with metastatic disease, interferon, chemotherapy, and octreotide may be helpful. In studies, the response to these
agents is low. Surgical resection may be attempted in patients with a single limited liver metastatic lesion.
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